Dear all,
Uppsala Pharmacometrics will give a 2.5-day course on “Advanced methods for
population model building and evaluation in NONMEM", 28-30 November, 2018 in
Boston, MA, USA. The course presents the latest methods for model evaluation,
strategies for model improvement as well as strategies to consider when
utilizing models for informed drug development. The course will provide tools
for fast, efficient and comprehensive model building, evaluation and usage.
The course will consist of lectures that describe and evaluate the various
strategies used to develop robust and useful population models as well as
hands-on computer exercises where students will actually use those strategies
in the classroom. The hands-on material will be based on the most recent
developments from NONMEM 7.4, PsN and Xpose.
Topics covered:
• Model evaluation
– Numerical
– Prediction-Based
– Residual-Based
– Empirical Bayes Estimate (EBE)-Based
– Simulation-Evaluation/Estimation-Based
– Covariate model focused diagnostics
– Parameter uncertainty
• Model improvement strategies
– Parameter variability
– Covariate models
– Residual error
– Handling censored data (BQL)
• To consider when applying models for informed drug development
– Type I and II errors
– Estimation methods
– Model averaging
Intended course participants:
The course is designed for those who have a good working knowledge of
pharmacometric analysis with experience in performing NONMEM analyses and/or
have attended a NONMEM basic workshop.
Support from Alnylam for facilities is greatly acknowledged.
For more information and registration, see
http://www.uppsala-pharmacometrics.com/build_diagnose_boston_2018.html
Best regards,
Andrew
Andrew Hooker, Ph.D.
Associate Professor of Pharmacometrics
Dept. of Pharmaceutical Biosciences
Uppsala University
Box 591, 751 24, Uppsala, Sweden
Phone: +46 18 471 4355
Mobile: +46 768 000 725
www.farmbio.uu.se/research/researchgroups/pharmacometrics/
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