GlaxoSmithKline (GSK) has an exciting position for a highly motivated 
Quantitative Clinical Pharmacologist to join our London team as a member of the 
global department of Clinical Pharmacology Modelling & Simulation. The job 
level will depend on the skills and achievements of the successful candidate. 
This is an excellent opportunity to use quantitative clinical pharmacology to 
accelerate the delivery of new medicines to patients by enhancing drug program 
efficiency and business decision quality.
Responsibilities:
*       Plan, execute and report translational drug-disease modelling, 
exposure-response analysis, simulation-based trial design and population 
clinical pharmacology
*       Contribute to asset clinical development and registration in terms of 
program plans, trial protocols, analysis plans, study reports and regulatory 
submissions
*       Assess and apply innovative techniques such as longitudinal 
exposure-response analysis, model-based meta-analysis and item-response 
analysis to maximise data use, trial efficiency and analytical power
*       Present strategy and discuss outcome of model-based approaches during 
interactions with internal governance boards and regulators
*       Promote model-informed drug discovery and development through external 
collaboration, journal publication and conference presentation

Requirements:
*       A doctorate in a field relevant to quantitative clinical pharmacology, 
and experience in using modelling/simulation to solve practical problems in 
industry or academia
*       Proven skills in pharmacokinetic-pharmacodynamic and longitudinal 
disease modelling; and verifiable proficiency in pharmacometric tools NONMEM, 
Monolix, R or SAS
*       Strong drive and learning agility to quickly build knowledge on a 
drug-disease system, symptom progression, trial design/endpoints and current 
treatments
*       Demonstrated aptitude for productive collaboration in a 
multi-discipline team, using effective communication and taking personal 
accountability for timely delivery of results
*       Clear evidence of ability to make sound judgement in complex situations 
and adapt to changing business needs by prioritising multiple tasks

At GSK, we develop therapies of various modalities for a broad range of 
indications. As a member of a global department with diverse expertise, you 
will enjoy a highly supportive environment for scientific innovation, business 
impact and professional growth. Interested persons are encouraged to apply 
online 
here<https://careers.peopleclick.com/careerscp/client_gsk/external1931/gateway.do?functionName=viewFromLink&jobPostId=406201&localeCode=en-us>.
Chao Chen
Clinical Pharmacology Modelling & Simulation
GlaxoSmithKline R&D

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