Hi Carlos, It is commonly used. For most datasets, there will be at least one observation that occurs before dosing to estimate the baseline value, and in almost every scenario, the modeling dataset should mirror the real world actions. So, there is no issue with it, and usually you will have an EVID=0 before the first dose.
Thanks, Bill -----Original Message----- From: owner-nmus...@globomaxnm.com <owner-nmus...@globomaxnm.com> On Behalf Of Carlos ST Sent: Wednesday, November 6, 2019 10:03 AM To: nmusers@globomaxnm.com Subject: [NMusers] Using evid 0 before dosing Dear NMUsers, I would like advice in the best practice to use evid 0 before dosing, which is to say an observation just before a dosing (*to estimate the value in that compartment just before dosing event). Thank you, Carlos,
