Dear Tingjie: When used in nonmem 7.5, a recommended example/setup would be (as shown on page 152 of nm750.pdf)
$SIZES ISAMPLEMAX=250 ... $EST METHOD=SAEM NBURN=500 NITER=1000 MASSRESET=1 ISAMPLE=2 PRINT=20 NOPRIOR=1 RANMETHOD=P $EST METHOD=SAEM NBURN=0 NITER=0 MASSRESET=0 ETASAMPLES=1 ISAMPLE=200 EONLY=1 $EST METHOD=IMP NITER=5 MASSRESET=1 ETASAMPLES=0 ISAMPLE=1000 EONLY=1 PRINT=1 MAPITER=0 Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com> <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835