niejian opened a new issue, #10595:
URL: https://github.com/apache/dubbo/issues/10595

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   - [x] I have searched the [issues](https://github.com/apache/dubbo/issues) 
of this repository and believe that this is not a duplicate.
   
   ### Environment
   
   * Dubbo version: 3.1.0
   * Operating System version: linux
   * Java version: 1.8
   
   ### Steps to reproduce this issue
   使用nacos注册中心,在接入k8s并集成istio后,由消费端调用提供者,提示报错如下:
   ```java
   
   
   SEVERE: Servlet.service() for servlet [dispatcherServlet] in context with 
path [] threw exception [Request processing failed; nested exception is 
org.apache.dubbo.rpc.RpcException: Failed to invoke the method getEmpInfo in 
the service cn.com.bluemoon.istio.demo.dubbo.service.CustEmpService. Tried 3 
times of the providers 
[istio-demo-dubbo-producer.istio-demo.svc.cluster.local:20885] (1/1) from the 
registry istio-demo-dubbo-producer.istio-demo.svc.cluster.local:20885 on the 
consumer 10.233.78.134 using the dubbo version 3.1.0. Last error is: Fail to 
invoke remote method: getEmpInfo, provider: 
tri://istio-demo-dubbo-producer.istio-demo.svc.cluster.local:20885/cn.com.bluemoon.istio.demo.dubbo.service.CustEmpService?application=istio-demo-consumer&background=false&check=false&interface=cn.com.bluemoon.istio.demo.dubbo.service.CustEmpService&lazy=true&mesh-enable=true&pid=11&provided-by=istio-demo-dubbo-producer&provider-port=20885&qos.accept.foreign.ip=true&qos.enable=false&register-m
 
ode=instance&register.ip=10.233.78.134&revision=1.0-SNAPSHOT&side=consumer&sticky=false,
 cause: org.apache.dubbo.rpc.StatusRpcException: UNAVAILABLE : upstream connect 
error or disconnect/reset before headers. reset reason: connection failure, 
transport failure reason: delayed connect error: 111
   --
   2022-09-09 14:28:52 | 
RemoteAddress:istio-demo-dubbo-producer.istio-demo.svc.cluster.local:20885] 
with root cause
   
   
   ```
   
   Pls. provide [GitHub address] to reproduce this issue.
   
   ### Expected Behavior
   
   <!-- What do you expect from the above steps?-->
   
   ### Actual Behavior
   
   <!-- What actually happens? -->
   
   If there is an exception, please attach the exception trace:
   
   ```
   Just put your stack trace here!
   ```
   


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