Here's an attempt with dynamic kerning based on the font, which eliminates some of the tweaking needed. It's not perfect and, depending on the font, a little work is needed. For pagella, scholas, termes, and a few other default fonts, the results are decent.
%\setupbodyfont[pagella] %\setupbodyfont[scholas] \setupbodyfont[termes] \starttext \newbox\MacMBox \setbox\MacMBox\hbox{M} \newbox\MacCBox \setbox\MacCBox\hbox{c} \newbox\MacKernBox \setbox\MacKernBox\hbox{\inframed[offset=\zeropoint, width=fit]{Mc}} \def\MacDelta{\dimexpr\wd\MacKernBox-\wd\MacMBox-\wd\MacCBox\relax} \def\MacUWidth{\dimexpr\wd\MacCBox-.75\MacDelta\relax} \def\MacRule{\vrule width \MacUWidth height .03em depth \zeropoint \relax} \def\MacKern{\dimexpr\wd\MacKernBox-\wd\MacMBox-\wd\MacCBox\relax} \def\Mac{% M{% \dontleavehmode{\raisebox{\dimexpr\ht\MacMBox-\ht\MacCBox}\hbox{c}}% \kern-1.04\MacUWidth \MacRule \kern.08\MacUWidth }% } \scale[scale=5000]{\Mac Anulty} \Mac Anulty \stoptext Thanks everyone!
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