Excessive items in the inbox will certainly cause Outlook to be sluggish, 
although I have not seen Outlook 2010 exhibit this as bad as previous versions. 
 Are these Outlook clients cached?

Another thing to look at on a 2003 server with slow networking is the TCP 
chimney issue from a couple years ago.  I have run across this a few times.   
http://support.microsoft.com/kb/912222


From: Holstrom, Don [mailto:dholst...@nbm.org]
Sent: Monday, October 25, 2010 9:00 AM
To: NT System Admin Issues
Subject: Remote Desktop slowing down

I have RDC on a Server 03, Exchange on an 08 machine. It appears that my RDC 
has been slowing. Many of those complaining have an excessive (to me) amount of 
items in their InBox: 8-15,000. I am using Office 10 on the 03 server. Anything 
I can look out for to speed things up? I re-built RDC recently, to make sure 
only those eligible are on the list. Still appears a bit slow...

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