Excessive items in the inbox will certainly cause Outlook to be sluggish, although I have not seen Outlook 2010 exhibit this as bad as previous versions. Are these Outlook clients cached?
Another thing to look at on a 2003 server with slow networking is the TCP chimney issue from a couple years ago. I have run across this a few times. http://support.microsoft.com/kb/912222 From: Holstrom, Don [mailto:dholst...@nbm.org] Sent: Monday, October 25, 2010 9:00 AM To: NT System Admin Issues Subject: Remote Desktop slowing down I have RDC on a Server 03, Exchange on an 08 machine. It appears that my RDC has been slowing. Many of those complaining have an excessive (to me) amount of items in their InBox: 8-15,000. I am using Office 10 on the 03 server. Anything I can look out for to speed things up? I re-built RDC recently, to make sure only those eligible are on the list. Still appears a bit slow... ~ Finally, powerful endpoint security that ISN'T a resource hog! ~ ~ <http://www.sunbeltsoftware.com/Business/VIPRE-Enterprise/> ~ --- To manage subscriptions click here: http://lyris.sunbelt-software.com/read/my_forums/ or send an email to listmana...@lyris.sunbeltsoftware.com<mailto:listmana...@lyris.sunbeltsoftware.com> with the body: unsubscribe ntsysadmin ~ Finally, powerful endpoint security that ISN'T a resource hog! ~ ~ <http://www.sunbeltsoftware.com/Business/VIPRE-Enterprise/> ~ --- To manage subscriptions click here: http://lyris.sunbelt-software.com/read/my_forums/ or send an email to listmana...@lyris.sunbeltsoftware.com with the body: unsubscribe ntsysadmin