https://www.genengnews.com/news/microprotein-could-point-to-new-therapeutic-targets-for-diverse-human-diseases/
This article from Genetic Engineering News doesn't specifically say origami anywhere, but I'm sure the word will work its way into the microprotein/unfolded protein response literature. "The Salk scientists have now characterized a 54 amino acid microprotein called PIGBOS, which their studies indicate may be key to molecular pathways involved in dealing with a particular form of cell stress. Cells routinely encounter stress that negatively impacts on cell health and function, the authors stated. The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a common stress, and this triggers a conserved pathway called the unfolded protein response (UPR), which acts to mitigate damage caused by this buildup. While stress-responsive genes, proteins, and pathways provide a cellular mechanism to cope with this form of cellular stress and return cells to homeostasis, dysregulation of the UPR underlies several debilitating diseases. “Cells with an insufficient capacity to handle protein production begin to accumulate unfolded or misfolded proteins, which causes ER stress and triggers UPR,” the authors commented. ”UPR dysfunction contributes to accumulation of key disease-related proteins, and thus plays an essential role in the pathogenesis of many neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.” Karen Reeds Princeton Public Library Origami Group Affiliate of Origami USA, http://origamiusa.org/ We usually meet 2nd Wednesday of the month, 6:30-8pm, 1st floor Quiet Room. Free! We provide paper! All welcome! (Kids under 8, please bring a grown-up.) Princeton Public Library info: 609.924.9529 https://princetonlibrary.org/ Celebrating 13 years of paperfolding in Princeton! *Our next meetings: * *Wed. Nov. 13, 2019, 6:30-8pm, Quiet Room, 1st Floor -- we'll fold Laura Kruskal's classic model, Holiday Turkey.* *Wed. Dec. 4, 2019,6:30-8pm, STEAM Room, 3rd Floor* [NB the FIRST Wednesday
