San Antonio Express-News
11 November 2007

http://www.mysanantonio.com/news/metro/stories/MYSA111007.03B.Guerra.3230773
.html


Carlos Guerra: Nation lacks a clearinghouse to monitor increase in biolabs

Web Posted: 11/09/2007 10:36 PM CST

San Antonio Express-News

This is the second of a series on San Antonio's role in the mushrooming
biodefense industry.

Since the anthrax scare of 2001 and the invasion of Iraq, the proliferation
of U.S. labs that are researching biohazardous agents that might be
"weaponized" has been mind-boggling.

The mention of "bioweapons" usually conjures images of organic agents being
aimed at humans to kill or incapacitate them. But there is also great
concern about potential bioweapons being used to attack food supplies or
other agricultural products that are critical.

Another specter raised to justify this massive proliferation is that growing
sophistication in the biosciences is making it possible to alter pathogens
or create new ones that are immune to known counter-agents.

These new possibilities, expansion proponents argue, make it necessary that
we expand research massively and quickly.

But developing "defenses," detractors counter, requires handling the
pathogens themselves. Uncontrolled expansion of labs with inadequate
supervision is increasing the chances for accidents or insider attacks.

These biolabs are categorized by "biosecurity levels."

BSL-1 and BSL-2 labs handle relatively safe materials that might be found in
high school and college labs.

BSL-3 labs handle agents whose potential for danger to researchers and the
public is sufficient that they must have special containment mechanisms to
prevent release of the toxins. Their researchers are also required to wear
protective garments and to observe strict protocols and report accidents.

The most dangerous are the BSL-4 labs, of which there are now only four,
though more are planned or being developed.

In these labs, containment requirements and lab and reporting protocols are
much stricter, and researchers must also be carefully screened. The
scientists must also wear air-tight suits equipped with their own air
supplies.

All of this is needed because they work with agents for which there are no
vaccines or cures.

In written testimony given in October to the U.S. House subcommittee that
oversees these labs, Edward Hammond, director of the U.S. office of the
Sunshine Project, tried to quantify the growth of BSL-3 and
BSL-4 labs as well as he could.

Since 2003, he later said in an interview, his group has been amassing
information on labs conducting this type of research. But he added that even
his information is incomplete because many university and privately funded
labs report to no one.

And federal funding comes from the National Institutes of Health and the
Departments of Defense, Agriculture and Homeland Security, each of which
imposes its own reporting requirements. What's more, there is no national
information clearinghouse, and federal agencies often call his group for
that.

"The incomplete list of new (BSL-3 and BSL-4) labs constitutes nearly
4 million square feet of new facilities, about 90 acres of space," he
testified.

"In perhaps a more recognizable measure, this is the equivalent of 36
typical 'big box' stores for the study of biological weapons and other
dangerous agents," he continued. "Placed end to end, with no space in
between, the row of stores would stretch 2.25 miles."

One of the BSL-4 labs is San Antonio's Southwest Foundation for Biomedical
Research, which operated a high-security lab as early as the 1970s, and
which has been a full-blown BSL-4 facility since the late 1990s. It also
maintains colonies of thousands of primates, which are valuable tools
because they are so genetically close to humans.

SFBR is a big reason San Antonio is a finalist for the National Bio and
Agro-Defense Facility, a mega BSL-4 operation.

We will look more closely at SFBR and the other consortium members, and
delve into why this proposed facility has grown so controversial.
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