http://www.physorg. <http://www.physorg.com/news116739098.html>
com/news116739098.html

Japan Scientists Develop Fearless Mice 

http://www.physorg.
<http://www.physorg.com/newman/gfx/news/1-japanscienti.jpg>
com/newman/gfx/news/1-japanscienti.jpg

In this undated photo released by Tokyo University's Department of
Biophysics and Biochemistry Graduate School of Science, a genetically
modified mouse approaches a cat in Tokyo. Using genetic engineering,
scientists at Tokyo University say they have successfully switched off the
rodents' instinct to cower at the smell or presence of cats, showing that
fear is genetically hardwired and not leaned through experience, as commonly
believed. (AP Photo/Ko and Reiko Kobayakawa, Tokyo University Department of
Biophysics and Biochemistry Graduate School of Science) 


(AP) -- Cat and mouse may never be the same. Japanese scientists say they've
used genetic engineering to create mice that show no fear of felines, a
development that may shed new light on mammal behavior and the nature of
fear itself. 

Scientists at Tokyo University say they were able to successfully switch off
a mouse's instinct to cower at the smell or presence of cats - showing that
fear is genetically hardwired and not learned through experience, as
commonly believed. 

"Mice are naturally terrified of cats, and usually panic or flee at the
smell of one. But mice with certain nasal cells removed through genetic
engineering didn't display any fear," said research team leader Ko
Kobayakawa. 

In his experiment, the genetically altered mice approached cats, even
snuggled up to them and played with them. Kobayakawa said he chose
domesticated cats that were docile and thus less likely to pounce. 

Kobayakawa said his findings, published in the science magazine Nature last
month, should help researchers shed further light on how the brain processes
information about the outside world. 

Kim Dae-soo, a neural genetics professor at the Korea Advanced Institute of
Science and Technology in Seoul, who was not involved in the research, said
Kobayakawa's research could explain further what fear is, and how to control
it. 

"People have thought mice are fearful of cats because cats prey on them, but
that's not the case," Kim said. 

"If we follow the pathway of related signals in the brain, I think we could
discover what kind of networks in the brain are important for controlling
fear." 
 
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