06/02/2011 04:17 PM

Mutant Bacteria


E. Coli Outbreak Linked to Aggressive New Strain


As the E. coli outbreak continues to ravage Germany and other parts of Europe, 
the World Health Organization said Thursday that the aggressive intestinal 
bacteria is a new strain never seen before. Meanwhile fears of the illness 
prompted Russia to ban imports of vegetables from the EU. 

Researchers are still desperately searching for the origin of the E. coli 
bacteria that has left 18 dead and infected hundreds of others in Germany and 
Europe. The number of cases within Germany continues to rise, with up to 2,000 
reported cases of infection, several hundred more than at the beginning of the 
week. Following the death of another victim in Hamburg overnight, the World 
Health Organization announced that preliminary genetic sequencing had revealed 
the deadly strain is likely a mutant form of two separate E. coli bacteria that 
is new to scientists.

The "unique strain has never been isolated from patients before" and has 
"various characteristics that make it more virulent and toxin-producing," WHO 
food safety expert Hilde Kruse told news agency AP. 

The mutant bacteria was identified through cooperation between scientists at 
the University Medical Center Hamburg-Eppendorf (UKE) and the Beijing Genomic 
Institute. "This strain is only a very distant relative of conventional EHEC 
bacteria," said UKE bacteriologist Holger Rohde.

The newly discovered enterohemorrhagic strain of the bacterium Escherichia coli 
(EHEC) causes watery or bloody diarrhea. In severe cases, EHEC also attacks the 
blood, kidneys and brain, causing a life-threatening complication known as 
hemolytic-uremic syndrome (HUS). Thousands of people in nine European countries 
have been infected by the bacteria, with nearly 500 developing the HUS 
complication. 

Outbreak Epicenter Germany 

Germany has suffered the greatest loss of life in the outbreak, with the latest 
death of an elderly woman at the University Medical Center Hamburg-Eppendorf 
(UKE) overnight bringing the death toll up to at least 17 in the country. Most 
of the victims have been women. A number of cases outside Germany have 
reportedly arisen in people who recently travelled there, officials said.

The swiftly spreading outbreak is baffling even the most experienced of 
doctors. "We are observing an unexpeced course of illness that has been unknown 
to us until now," said Hendrik Lehnert, director of the clinic at Lübeck's 
University Medical Center Schleswig-Holstein. 

But hope may lie in an antibody being tested at several clinics, the results of 
which will be presented on Friday. Doctors are only cautiously optimistic, 
though. "It has some effect, but it's no wonder drug," said Hermann Haller, the 
director of Hannover Medical School's Clinic for Nephrology.

Spanish Cucumbers No Longer Suspected 

In the meantime experts have ruled out their initial suspicion 
<http://www.spiegel.de/international/germany/0,1518,765114,00.html>  that 
Spanish cucumbers were the source of the E. coli bacteria, though they still 
believe vegetables are the likely culprit. It turns out that after more 
thorough examination, the four cucumbers tested in Hamburg and linked to Spain 
last week did not carry the same strain isolated in patients, the Federal 
Institute for Risk Assessment (BfR) reported. 

"The source of the ongoing infections has not yet been determined," said BfR 
President Andreas Hensel. "Furthermore, it has to be clarified at what point in 
the food chain the contamination with germs occurred."

The EU commission has since removed its warning against Spanish cucumbers, but 
Prime Minister Jose Luis Rodriguez Zapatero told a national radio station that 
his country would seek reparations from European authorities to cover farmers' 
losses. Germany's Consumer Ministry defended the preventative measures. Hamburg 
authorities acted in accordance with regulations, spokesman Holger Eichele said 
in Berlin.

Russia Bans EU Vegetables 

The outbreak also prompted Russia on Thursday to ban the import of vegetables 
from the entire European Union, a move the commission health spokesman Frederic 
Vincent called "disproportionate." 

The commission will write a letter to Russian authorities demanding an 
explanation, he said, adding that fresh fruit and vegetable exports to Russia 
amount to between €3 billion and €4 billion ($4.3 billion and $5.8 billion) per 
year, primarily in apples. 

Despite the EU's criticism, Germany's disease control authority, the Robert 
Koch Institute, maintained its warning against eating raw tomatoes, cucumbers 
and lettuce until the source of the bacteria could be found. Experts remain 
uncertain whether it arises during transport, loading, or packaging the 
products. 

However, experts said it was unlikely the bacteria's source would be located 
quickly, if at all. "In the majority of outbreaks the agent is never isolated," 
said Andreas Hensel of the Federal Institute for Risk Assessment (BfR). 

-- kla, with wires





URL:


*       http://www.spiegel.de/international/europe/0,1518,766312,00.html

 



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