> When I apply a threshold filter and view as a ‘Surface’ the image is a lot 
> more ‘blocky’ than in the other two applications.  The image is dominated by 
> the artifactual lines due to the original data being acquired as axial 
> slices; whereas in OsiriX and 3D Slicer this gets smoothed out and the 
> ‘genuine’ surface skull features (sutures etc) stand out.

Try using the "Contour" filter instead of Threshold. That will give
you a surface mesh. If you want to generate a volumetric dataset, use
the "Clip" filter with "Clip Type" set to Scalar and then enter the
scalar value to clip at.
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