>the Commerce Clause refers to the role of the US federal government in 
regulating interstate commerce (from the original constitution), right? 
when was it reinterpreted  in a relatively progressive way? what were the 
political forces and struggles behind that reinterpretation?

This was the struggle around the New Deal. To deal with depression, the government 
needed to do things like OK labor unions and generally regulate the economy. The old 
commcer clause and equal protection jurisprudence didn't allow this. The standard, not 
wholly accurate, story is that after the Court zapped the National Recovery 
Administration, Roosevelt threatened to "pack the court" by getting more Justices on 
it. That was shot down, but in response to popular outrage a key swing justice, Owen 
Roberts "switched" and started voting to uphold New Deal Programs in cases like West 
Coast Hotel, Carolene Products, and Jones & Laughlin Steel. 

--jks

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