Hari, are you saying that NO was patented? Tell me more!!!
On Sat, Jul 29, 2006 at 03:41:41AM -0400, Hari Kumar wrote: > Leigh Meyers <[EMAIL PROTECTED]> > "Isn't Nitric Oxide =3D NOX, the bad-bad emmision from cars, one of the=20 > first things to be smog-controlled after the 'draft tube' went and pcv=20 > valves sprouted on engines like little silver mushrooms? > If so, is it ok to drive my Lincoln Navigator down to... Children's=20 > Hospital of Philadelphia... and idle it outside the preemie ward for a bit? > > Inhaled Nitric Oxide Reduces Lung Disease in Premature Babies > http://www.newswise.com/articles/view/522202/?sc=3Ddwhn > > Hello: > Definitely not a chemist - but an RCT-ologist. > i) NO + O2 -> peroxynitrites = heavily toxic to lungs by creation of oxygen > free radicals. > ii) Concentration of inhaled NO (iNO) is low - and does not create high local > peroxynitrites. > iii) Local effects in lungs does vasodilate lung blood vessels. Different > from an effect of inhaling the gas in large atmosphere with o2. > iv) NO & preterms likely a subgroup analysis - as one RCT-ologist says, > beware the sirens of subgroup analysis. > Likely NO helps only helps one smaller area of infant disease - where the BP > in the lungs extremely high (left-over from being an in-utero advantage = > 'Persistent Pulmonary Hypertension Newborn'). Usually problem in term - not > preerm - babies. > v) Do not idle your car if you feel any smidgen of Green-ness -or preventive > health care advocacy. Do ont now enough about it, but I think emissions > contain other nasty stuff. > > AS another economic aspect of this: > -No as a health agent discovered in Boston; > - The gas was 'patented' > - The RCT's were funded by public purse (CIHR; NIH) > - Upon demonstration of efficacy & low risk in a particular patient > population (to wit: high BP = 'PPHN') -> the patent exercised > - Overnight the cost rocketed up. > - In EEC - court challenge effective. > - In USA & Canada -> legal & patent challenges ineffective. > Almost singled-handedly, this agent will introduce a huge cost escalation > into hospital budgets by virtue of this agent. > - Hence lot of (on present data at least) hyped claimes for NO. > > H -- Michael Perelman Economics Department California State University Chico, CA 95929 Tel. 530-898-5321 E-Mail michael at ecst.csuchico.edu
