Yes, I've gained about 70lbs and nothing I try seems to work at losing it. My ring size has also changed, but I just figured it was because the rest of me was bigger too. Dr. Ludlam said he thought I might have Cushings, but until they do a full assessment there's no way to tell for sure what all is happening. I actually look I'm pregnant, just without the 'baby belly'. It's all just fat hehe. The shoe size change was something I just thought was a bit of a weird thing, but never dreamt it could be because of pituitary disease. I so hope that this referral goes through without a problem and that I can finally find out what is going on. Finding this site and hearing other's stories has given me hope when I thought all was lost. Does it really get better? Is there hope that I might lose some of the weight, and stop feeling so tired and ill after they fix this? Cathy | 