[[ Idiots who use illegal drugs do so at their own risk. If a cocaine user
gets pepper sprayed and suffers consequences it it his own damn fault and
neither the police nor the state is at fault nor are they liable. ]]



http://www.newscientist.com/article/mg20427345.300-cocaine-and-pepper-spray--a-lethal-mix.html?full=true&print=true


Cocaine and pepper spray – a lethal mix?

   - 13 November 2009 by *Shanta
Barley*<http://www.newscientist.com/search?rbauthors=Shanta+Barley>

DEATHS in US police custody during the early 1990s may have been the result
of an interaction between capsaicin, the key ingredient in pepper sprays,
and psychostimulant drugs, an experiment in mice suggests.

If the two have a fatal interaction in people then police forces might have
to rethink their use of pepper spray as a non-lethal weapon, says John
Mendelson<http://www.cpmc.org/professionals/research/programs/addiction.html>of
the Addiction and Pharmacology Research Laboratory at St Luke's
Hospital
in San Francisco, who led the mouse research.

In the early nineties, anecdotal reports emerged in the US of people dying
after being sprayed by police. "They seemed to die very quickly," says
Mendelson. At post-mortem, many of these people showed signs of having taken
cocaine, so Mendelson wondered if capsaicin and cocaine could interact
fatally in the body.

To investigate, his team injected cocaine, capsaicin or both at once into
the abdomens of several groups of about 30 mice. Injections allowed them to
control the dose of capsaicin the mice received, which wouldn't have been
possible if the mice were simply sprayed, says Mendelson.

In one group of mice, cocaine was injected at a dose of 60 milligrams per
kilogram of mouse weight, which killed just a few of them. But when the
researchers injected a group with the same dose of cocaine plus capsaicin,
the death toll was about half. "The presence of capsaicin in mice makes
smaller amounts of cocaine more lethal," Mendelson says. When the team gave
another group of mice capsaicin along with a higher dose of cocaine - enough
to kill half of the mice on its own - the death toll rose to 90 per
cent (*Forensic
Toxicology*, DOI:
10.1007/s11419-009-0079-9<http://dx.doi.org/10.1007/s11419-009-0079-9>).
"We don't actually know how capsaicin reacts with cocaine to produce a
lethal effect," admits Mendelson.

However, his team also reviewed 26 autopsy reports and Californian police
reports between 1993 and 1995 of people who died shortly after being subdued
with pepper spray. They noted that 19 of them had evidence of
psychostimulants in their blood and nine had cocaine. Mendelson suspects
that a fatal interaction takes place in the brain between capsaicin and
psychostimulants.

Toxicologists are intrigued, but say further evidence is needed. "In
real-life situations, humans inhale pepper spray, whereas these mice had the
substance injected directly into their abdominal cavities," says Andy
Smith<http://www.mrc.ac.uk/Newspublications/News/MRC004090>of the
Medical Research Council in Cambridge, UK. Kathryn
Cunningham <http://www.utmb.edu/phtox/facultyindv.asp?intFacID=1> of the
Department of Pharmacology and Toxicology at the University of Texas in
Galveston says we don't know how much of the capsaicin that is sprayed in
someone's face makes it into their bloodstream.

Peter 
Bibring<http://www.superlawyers.com/california-southern/lawyer/Peter-Bibring/ff5f2de1-be87-45af-ba3e-54a0765ee091.html>,
an attorney at the American Civil Liberties Union in Los Angeles, says the
study adds weight to the ACLU's concern that pepper spray could be fatal.
"Police departments need to make adjustments to minimise the chance it will
be used on those under the influence of cocaine."

Norm Leong <http://www.sacpd.org/newsroom/releases/>, a sergeant at the
Sacramento Police Department in California says this could be a tough call:
"It's impossible to know if someone is under the influence of cocaine, some
other drug", has mental issues, or is just resisting arrest.

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