I found out that my Yubikey works on gnupg-2.4.3 after disabling CCID in scdaemon by adding "disable-ccid" to "~/.gnupg/scdaemon.conf" :)
$ man scdaemon [...] --disable-ccid Disable the integrated support for CCID compliant readers. This allows falling back to one of the other drivers even if the internal CCID driver can handle the reader. Note, that CCID support is only available if libusb was available at build time. [...] $ cat ~/.gnupg/scdaemon.conf reader-port "Yubico YubiKey FIDO+CCID 00 00" disable-ccid $ For some reason that wasn't needed in previous versions. Maybe we should mention that option in the pkg/README. -- Renato Aguiar