Tadi malam diumumkan siapa-siapa pemenang Hadiah Nobel
untuk kimia tahun 2004 ini. Nama-nama mereka adalah
Aaron Ciechnova, Avram Hershko dan Irwin Rose. Dua
orang yang disebut pertama, yaitu Aaron Ciechnova dan
Avram Hershko sama-sama mengajar di Technion (Israel
Institute of Technology) di Haifa. Sedang Irwin Rose
mengajar di University of California Irvine.
Salam,
RM
Science Daily
Source: The Nobel Foundation
Date: 2004-10-06
Nobel Prize In Chemistry: Proteins Labelled For
Destruction
Proteins build up all living things: plants, animals
and therefore us humans. In the past few decades
biochemistry has come a long way towards explaining
how the cell produces all its various proteins. But as
to the breaking down of proteins, not so many
researchers were interested. Aaron Ciechanover, Avram
Hershko and Irwin Rose went against the stream and at
the beginning of the 1980s discovered one of the
cell's most important cyclical processes, regulated
protein degradation. For this, they are being rewarded
with this year's Nobel Prize in Chemistry.
Aaron Ciechanover, Avram Hershko and Irwin Rose have
brought us to realise that the cell functions as a
highly-efficient checking station where proteins are
built up and broken down at a furious rate. The
degradation is not indiscriminate but takes place
through a process that is controlled in detail so that
the proteins to be broken down at any given moment are
given a molecular label, a ‘kiss of death', to be
dramatic. The labelled proteins are then fed into the
cells' "waste disposers", the so called proteasomes,
where they are chopped into small pieces and
destroyed.
The label consists of a molecule called ubiquitin.
This fastens to the protein to be destroyed,
accompanies it to the proteasome where it is
recognised as the key in a lock, and signals that a
protein is on the way for disassembly. Shortly before
the protein is squeezed into the proteasome, its
ubiquitin label is disconnected for re-use.
Thanks to the work of the three Laureates it is now
possible to understand at molecular level how the cell
controls a number of central processes by breaking
down certain proteins and not others. Examples of
processes governed by ubiquitin-mediated protein
degradation are cell division, DNA repair, quality
control of newly-produced proteins, and important
parts of the immune defence. When the degradation does
not work correctly, we fall ill. Cervical cancer and
cystic fibrosis are two examples. Knowledge of
ubiquitin-mediated protein degradation offers an
opportunity to develop drugs against these diseases
and others.
Aaron Ciechanover, born 1947 (57 years) in Haifa,
Israel (Israeli citizen). Doctor's degree in medicine
in 1981 at the Technion (Israel Institute of
Technology), Haifa. Professor at the Unit of
Biochemistry and Director of the Rappaport Family
Institute for Research in Medical Sciences at the
Technion, Haifa, Israel.
Avram Hershko, born 1937 (67 years) in Karcag, Hungary
(Israeli citizen). Doctor's degree in medicine in 1969
at the Hadassah Medical School of the Hebrew
University, Jerusalem. Distinguished Professor at the
Rappaport Family Institute for Research in Medical
Sciences at the Technion (Israel Institute of
Technology), Haifa, Israel.
Irwin Rose, born 1926 (78 years) in New York, USA
(American citizen). Doctor's degree in 1952 at the
University of Chicago, USA. Specialist at the
Department of Physiology and Biophysics, College of
Medicine, University of California, Irvine, USA.
Prize amount: SEK 10 million, will be shared equally
among the Laureates.
This story has been adapted from a news release issued
by The Nobel Foundation.
------------------------ Yahoo! Groups Sponsor --------------------~-->
$9.95 domain names from Yahoo!. Register anything.
http://us.click.yahoo.com/J8kdrA/y20IAA/yQLSAA/BRUplB/TM
--------------------------------------------------------------------~->
***************************************************************************
Berdikusi dg Santun & Elegan, dg Semangat Persahabatan. Menuju Indonesia yg Lebih
Baik, in Commonality & Shared Destiny. www.ppiindia.shyper.com
***************************************************************************
__________________________________________________________________________
Mohon Perhatian:
1. Harap tdk. memposting/reply yg menyinggung SARA (kecuali sbg otokritik)
2. Pesan yg akan direply harap dihapus, kecuali yg akan dikomentari.
3. Lihat arsip sebelumnya, www.ppi-india.da.ru;
4. Posting: [EMAIL PROTECTED]
5. Satu email perhari: [EMAIL PROTECTED]
6. No-email/web only: [EMAIL PROTECTED]
7. kembali menerima email: [EMAIL PROTECTED]
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ppiindia/
<*> To unsubscribe from this group, send an email to:
[EMAIL PROTECTED]
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/
