http://www.antaranews.com/en/news/84260/aspirin-may-help-men-with-prostate-cancer-live-longer
Aspirin may help men with prostate cancer live longer
Thu, August 30 2012 21:31 | 

 
Kevin Choe. (utsouthwestern.edu)

  "The results from this study suggest that aspirin prevents the growth of 
tumor cells in prostate cancer." 
Washington (ANTARA News/Xinhua-OANA) - Men who have been treated for prostate 
cancer, either with surgery or radiation, could benefit from taking aspirin 
regularly, according to a U.S. study published this week in the Journal of 
Clinical Oncology.

Taking aspirin is associated with a lower risk of death from prostate cancer, 
especially for men with high-risk prostate cancer, according to the study. 
Kevin Choe, assistant professor of radiation oncology at the University of 
Texas Southwestern Medical Center, is first author of the paper.

Preclinical studies have shown that aspirin and other anticoagulation 
medications may inhibit cancer growth and metastasis, but clinical data have 
been limited previously.

The new study looked at almost 6,000 men who had prostate cancer treated with 
surgery or radiotherapy. About 2,200 of the men involved, or 37 percent, were 
receiving anticoagulants ( warfarin, clopidogrel, enoxaparin, and/or aspirin). 
The risk of death from prostate cancer was compared between those taking 
anticoagulants and those not.

The findings demonstrated that 10-year mortality from prostate cancer was 
significantly lower in the group taking anticoagulants, compared to the 
non-anticoagulant group, or three percent versus eight percent. The risks of 
cancer recurrence and bone metastasis also were significantly lower. Further 
analysis suggested that this benefit primarily derived from taking aspirin, as 
opposed to other types of anticoagulants.

The suggestion that aspirin, a frequently prescribed and relatively 
well-tolerated medication, may improve outcomes in prostate cancer is of 
particular interest, Choe said, noting that prostate cancer is the most common 
non-skin cancer among men and the second-leading killer cancer in the United 
States.

"The results from this study suggest that aspirin prevents the growth of tumor 
cells in prostate cancer, especially in high-risk prostate cancer, for which we 
do not have a very good treatment currently," Choe said in a statement.

"But we need to better understand the optimal use of aspirin before routinely 
recommending it to all prostate cancer patients."
(U.C003)

[Non-text portions of this message have been removed]



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