On Sep 19, 2006, at 9:22 AM, Kashyap, Vipul wrote:
In preparation of the BIONT Telecon today,
The latest version of the Parkinson’s Disease Ontology in OWL is
available at:http://esw.w3.org/topic/HCLS/OntologyTaskForce/
SeedOntology/
OWL-DL axioms that model some of the “facts” identified by Bill Bug
are available at the bottom of:http://esw.w3.org/topic/HCLS/
OntologyTaskForce/SeedOntology/SeedOntologyDetailedFollowup
Some quick comments:
Reduced ubiquitin C-terminal hydrolase-1 expression levels in
dementia with Lewy bodies.
Ubiquitin C-terminal hydrolase-1 subclass-of Protein
Dementia subclass-of Disease i Do we need to model a class for
Patient?
Introduce Axiom: (someValuesFrom has-disease Dementia) subclass-of
(hasValue expression-level reduced)
You need patient or at least organism, or you need to roll the
organism into the relation.
Things which have diseases are organisms, so (someValuesFrom has-
disease Dementia) is a subclass of say, organism.
Things which have expression levels, or amounts are, e.g. proteins so
(hasValue expression-level reduced) is a subclass of say, protein.
One would think that organisms and proteins be disjoint classes. Two
subclasses of two disjoint classes are also disjoint.
(someValuesFrom has-disease Dementia) subclass-of (hasValue
expression-level reduced) is read as
All things which are (someValuesFrom has-disease Dementia) = some set
of organisms are also
(hasValue expression-level reduced) = some set of proteins.
Which says that some organisms are proteins, which by the disjoint
would be unsatisfiable.
So you need to make sure that the two halves of the subclass relation
are of appropriate kinds. One way to do this would be to model
something like "humans which have lower values of total expression of
uclh1 measured in samples of their medulla oblongata". This is a
subset of humans, and so the subclass relation you propose would say
that one set of humans (those with dememtia) are a subset of another
set of humans (those which have lower values of total expression of
uclh1 measured in samples of their medulla oblongata).
Ok, got to go. Speak to you soon.
-Alan
