Thanks to Jeremy Zucker for pointing this out to me.
http://vcp.med.harvard.edu/tl-schedule.html
HMS, Alpert Building, Room 563 at 12 noon
Towards knowledge-based semantic integration of models
12 Oct 2007
Carolyn Talcott
Computer Science Lab
SRI International
Abstract
In spite of standards efforts such as SMBL and BioPax it remains
difficult to share models of biological processes (for example signal
transduction or metabilism). It is even more difficult to combine
models of similar processes developed by different researchers not to
mention models of different processes/aspects, to obtain a bigger
picture.
I will present some preliminary thoughts on a possible approach to
improving the situation based on an attempt to represent the
biological knowledge underlying the models in a framework that is
(hopefully) independent of specific analysis tools (MatLab,
PRISM ...) but that supports reasoning about the knowledge.
I will also discuss some of the specific issues that arose in a
modest case study of models of signaling due to EGF stimulation. I
will also mention similar issues that arise when importing models
from publicly avaialable data bases.
Hopefully this will elicit discussion of additional issues that must
be faced and lead to some productive brainstorming about how to make
progress in practice.