Hi Eric,
I'm not an expert, but this seems a bit hard to answer. Bapineuzumb does not
seem to bind or directly regulate Apolipoprotein and its variants. The APOE4
allele is merely a biomarker which can be used to stratify the patient
population into likely responders and non-responders. Looking at the HCLS
KB, TMKB and http://lod.openlinksw.com, the (almost) only information that
can be found about Bapineuzumab are clinical trials from LinkedCT.
hypothesis.alzforum.org does not have much either, unfortunately.
- Matthias
--------------------------------------------------
From: "Eric Prud'hommeaux" <e...@w3.org>
Sent: Monday, February 14, 2011 10:37 PM
To: <public-semweb-lifesci@w3.org>
Cc: "Helena Deus" <helenad...@gmail.com>
Subject: beefing up PharmaOntology Queries #Q6
Query six¹ matches patients without the APOE4 allel, putatively to
match the inclusion criterial for a clinical trial involving
Bapineuzumab. Do we have any drug data which links Bapineuzumab to
APOE4, so that we query for *any* protein regulated by Beelzebub,
rather than specifically APOE4?
¹
http://www.w3.org/wiki/HCLSIG/PharmaOntology/Queries#Q6._Are_there_any_AD_patients_without_the_APOE4_allele_as_these_would_be_good_candidates_for_the_clinical_trial_involving_Bapineuzumab.3F
--
-ericP
