I came here searching for a different wxpython issue, but suspect I know 
the problem here, as I ran into it a while back. You should set the 
NSHighResolutionCapable flag in your info.plist file. You can do this in 
the BUNDLE method using the info_plist command, or manually set it. Here's 
an example from a program I maintain (where coll is the output of the 
COLLECT):

if opsys == 'Darwin':
    app = BUNDLE(
        coll,
        name='RAW.app',
        icon=raw_icon,
        bundle_identifier='edu.bioxtas.raw',
        info_plist=
            {
            'CFBundleVersion' : RAWGlobals.version,
            'CFBundleShortVersionString' : RAWGlobals.version,
            'LSBackgroundOnly' : '0',
            'NSHighResolutionCapable' : True,
            'NSPrincipleClass' : 'NSApplication',
            'CFBundleDevelopmentRegion' : 'en_US',
            'LSHasLocalizedDisplayName' : False,
            'CFBundleDocumentTypes' : [
                {
                    'CFBundleTypeName' : 'SAXS data file',
                    'LSHandlerRank' : 'Default',
                    'CFBundleTypeExtensions': ['out', 'fit', 'fir', 'rad',
                        'int', 'dat', 'csv', 'sub', 'txt'],
                    'CFBundleTypeRole' : 'Viewer'
                },
                {
                    'CFBundleTypeName' : 'Image file',
                    'LSHandlerRank' : 'Default',
                    'CFBundleTypeExtensions': ['tif', 'tiff', 'nxs', 'edf',
                        'ccdraw', 'img', 'imx_0', 'dkx_0', 'dxk_1', 'png',
                        'mpa', 'mar1200', 'mar2400', 'mar3200', 'mar3600',
                        'sfrm', 'dm3', 'xml', 'cbf', 'kccd', 'msk',
                        'spr', 'h5', 'mccd', 'mar3450', 'npy', 'No'],
                    'CFBundleTypeRole' : 'Viewer'
                },
                {
                    'CFBundleTypeName' : 'LC data file',
                    'LSHandlerRank' : 'Default',
                    'CFBundleTypeExtensions': ['sec',],
                    'CFBundleTypeRole' : 'Viewer'
                },
            ],
            },
        )

If it's already installed and you overwrite the .app, you might have to 
force MacOS to update the changes, this set of commands should do it:
/System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister
 
-f /Applications/<my_app>.app 
/System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister
 
-kill -seed 
/System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister
 
-f /Applications -all local,user

You may then have to right click on the .app, select ‘Get Info’ and uncheck 
the box ‘Open in low resolution mode’.

Hope that helps.

- Jesse

On Tuesday, February 2, 2021 at 10:42:47 AM UTC-6 [email protected] 
wrote:

> For a GUI application built with wxPython I noticed the GUI becomes all 
> blurry after it is compiled into a binary with PyInstaller. Tried both 3.6 
> and 4.2 but the effect is largely the same.
> Build environement: macOS Big Sur, same with previous versions
>
> Has one of you seen a similar behavior and/or an idea how to fix this?
>
> *Running Python app*
> [image: Screen Shot 2021-02-01 at 22.56.33.png]
>
> ➜  NodeMCU-PyFlasher git:(master) ✗ python3 --version
> Python 3.8.2
>
> *Running the binary*
> [image: Screen Shot 2021-02-01 at 22.57.15.png]
>
> Thanks
>

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