You should address this question to the SQLAlchemy mailing list as it's unrelated to Pyramid, but basically as you said, it's a hard problem that will not be solved simply by changing the property on the column in your class definition. You will need to learn how to mutate the underlying database, by executing raw sql, through some interface for your database, or via the sqlalchemy-migrate package. You should also note that not every database backend supports changing constraints.
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