Okay, it seems that "set auto_zoom, off" does work for PDB files, but not 
for SDF files.  I have a python script that gives these three commands:

set auto_zoom, off
load gsk_77553_l.sdf
show sticks, gsk_77553_l

But when you call the script, this is what happens in pymol

PyMOL>set auto_zoom, off
 Setting: auto_zoom set to off.
PyMOL>load gsk_77553_l.sdf
 Executive: object "gsk_77553_l" created.
PyMOL>zoom (gsk_77553_l)
PyMOL>show sticks, gsk_77553_l

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