Charles-François Natali added the comment:

This doesn't look thread-related:
"""
load: 0.50  cmd: python 10630 [runnable] 0.27u 13.07s 46% 10976k
load: 0.87  cmd: python 10630 [runnable] 0.27u 94.24s 98% 10976k
"""

See the huge system time?
This probably means that the kernel is struggling with path name
resolution, although that's surprising because 4099 is a reasonable
limit.
Do you have something like strace or truss on NetBSD?
The first thing to try could be to lower the limit, and see what
happens, but it's really likely a FS scalibility limit you're hitting
(altough, once again, that's really surprising given the reasonable
limit). Are you running those under VMs?

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue15765>
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