Antoine Pitrou added the comment:

Some crude C benchmarking on this computer:
- calling PyUnicode_Replace is 35 ns (per call)
- calling "hundred".replace is 125 ns
- calling PyArg_ParseTuple with the same signature as "hundred".replace is 80 ns

Therefore, most of the overhead (125 - 35 = 90 ns) is in calling 
PyArg_ParseTuple() to unpack the method arguments.

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue17170>
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