Raymond Hettinger added the comment:

Additional effect:  Destabilizes lots of code that has had a decade to mature.  
It messes with the compiler, the eval loop, the peephole optimizer, the 
disassembler, every third-party tool that examines or alters byte codes, any 
tool or VM that implements python byte codes, etc.  Changes like this tend to 
invalidate previous efforts to time and optimize code.

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nosy: +rhettinger

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<http://bugs.python.org/issue17611>
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