Ned Deily added the comment: As David notes, this issue does not document any problems with Python 3.5 itself. I see at least two issues here. One, you are using virtualenv, a third-party package, rather than Python's built-in venv. It appears that the most recent release of virtualenv on PyPI, virtualenv 13.1.2, includes outdated wheels of other third-party products, in particular, of wheel: 0.24, instead of the current 0.36 (https://pypi.python.org/pypi/wheel). If you update wheel in your virtualenv that should fix the "assert tag == supported_tags[0]" issue. Suggest you open an issue against virtualenv to ask that they update their vendored packages or perhaps not include them. Another problem, when using the python.org python3.5, is with the install script of the uwsgi, uwsgiconfig.py. The script does some machinations to figure out what compiler it is using. Unfortunately, it seems to get confused by the fact that, with the last several major releases of Xcode, Apple no long ships gcc but does provi de a gcc alias that actually invokes clang. If you override the CC value and explictly set CC=clang, the uwsgi install seems to work correctly with the python.org OS X 3.5.0. I do not have a homebrew installation handy to check, so if there are other problems after updating wheel in your virtualenv (or switching to use builtin venv) and using CC=clang, suggest you ask on a homebrew forum.
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