Steve Dower added the comment:

MSVC has had Link-Time Code Generation for many releases, and it should have 
been used for all 2.7 releases (definitely used in 3.5+) to optimize references 
between object files. I assume this is equivalent to LTO.

We currently don't use PGO in the official Windows builds, but it is a 
supported build configuration.

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<http://bugs.python.org/issue25702>
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