Ned Deily added the comment:

The issue here seems to be the way Twisted installs its dependencies.  It looks 
like Twisted is calling setuptools directly and thus probably "losing" the 
certificate-related arguments from the original pip call.  (It all works 
correctly if do you the default root certificates setup as suggested in the 
installer readme.)  If you want to pursue the issue, I suggest checking with 
the Twisted project (https://twistedmatrix.com/).

----------
assignee: christian.heimes -> 
resolution:  -> third party
stage:  -> resolved
status: open -> closed

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue29066>
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