STINNER Victor added the comment:

I ran benchmarks on tp_fastcall.patch. Hum, it seems like there is a 
performance issue somewhere :-( Almost all benchmarks are much slower with the 
patch.

haypo@speed-python$ python3 -m perf compare_to 
2017-01-11_00-07-default-b9404639a18c.json tp_fastcall_ref_b9404639a18c.json -G
Slower (63):
- unpickle_pure_python: 671 us +- 16 us -> 952 us +- 9 us: 1.42x slower (+42%)
- pickle_pure_python: 1.02 ms +- 0.02 ms -> 1.40 ms +- 0.02 ms: 1.37x slower 
(+37%)
- telco: 16.6 ms +- 0.6 ms -> 22.7 ms +- 0.3 ms: 1.37x slower (+37%)
- xml_etree_generate: 215 ms +- 3 ms -> 290 ms +- 7 ms: 1.35x slower (+35%)
- hexiom: 17.7 ms +- 0.2 ms -> 23.6 ms +- 0.1 ms: 1.33x slower (+33%)
- xml_etree_process: 182 ms +- 3 ms -> 240 ms +- 4 ms: 1.32x slower (+32%)
- genshi_text: 69.0 ms +- 0.8 ms -> 90.4 ms +- 0.8 ms: 1.31x slower (+31%)
- logging_simple: 27.5 us +- 0.4 us -> 35.8 us +- 0.4 us: 1.30x slower (+30%)
(...)

Faster (1):
- spectral_norm: 271 ms +- 2 ms -> 257 ms +- 2 ms: 1.06x faster (-5%)

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<http://bugs.python.org/issue29259>
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