STINNER Victor added the comment:

Ok, I confirm that it's possible to compile and install Python using PGO+LTO 
without --enable-optimizatioins:

cd ~/cpython
make distclean ||:
./configure --with-lto --prefix=/home/haypo/installed/3.7
make clean
make profile-opt
make install

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<http://bugs.python.org/issue29641>
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