Xiang Zhang added the comment:

There seems no significant regression in performance. A microbenchmark against 
nu_longlong:

./python3 -m perf timeit --duplicate=1000 --compare-to 
/home/angwer/repos/cpython/python -s 'import struct; p = struct.Struct("@L")' 
'p.unpack(b"d\x00\x00\x00\x00\x00\x00\x00")'
python: ..................... 156 ns +- 10 ns
python3: ..................... 157 ns +- 9 ns

Median +- std dev: [python] 156 ns +- 10 ns -> [python3] 157 ns +- 9 ns: 1.01x 
slower
Not significant!

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<http://bugs.python.org/issue30224>
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