Matt Ripley <matt.rip...@yahoo.co.uk> added the comment:

Hi Steve,
Finally sorted this out. I tried all the workarounds that I could find on the 
web for similar issues. In the end I needed to re-image windows 10. This was 
the only thinkg that sorted it out. So looked like the windows had ccorrupted 
preventing the msi installers.
Thanks for your help.
Best regards
Matt

      From: Steve Dower <rep...@bugs.python.org>
 To: matt.rip...@yahoo.co.uk 
 Sent: Sunday, 28 January 2018, 12:05
 Subject: [issue32545] Unable to install Python 3.7.0a4 on Windows 10 - Error 
0x80070643: Failed to install MSI package.

Steve Dower <steve.do...@python.org> added the comment:

>From the log file, all I can tell is that it failed to open the file 
>containing information about ongoing installs. At a guess, another install was 
>running (maybe failed?) and didn't clean up properly.

Rebooting should generally resolve that. If it doesn't, you're either looking 
at serious OS corruption (worth testing if any other MSI installers work - 
Anaconda does not use MSI) or disk corruption.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue32545>
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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue32545>
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