STINNER Victor <vstin...@redhat.com> added the comment:

> I don't think this should be merged.  A lot of code of uses 
> PyTuple_GET_ITEM(). Also, the "problem" your solving doesn't seem to exist in 
> practice.

Sorry my comment on the PR, a friend contacted me because (...) he misused 
PyTuple_GET_ITEM() :-)

> Further, I worry that a compiler may choose not to inline on occasion, 
> leading to performance regressions in code that has already been finely tuned.

Oh, maybe I didn't explain properly my change. I don't want to change the 
"default" API nor the "default" implementation. My change is enabled enabled if 
you compile Python in debug mode, if Py_DEBUG is defined.

In fact, it's an early attempt to see how we can introduce a new C API in 
Python. It seems like abusing Py_DEBUG was a bad idea, so I close my PR and I 
will close this issue as well. I will start a discussion on python-dev later, 
when I will have a plan.

See also the discussion on the PR:
https://github.com/python/cpython/pull/10435#issuecomment-437530430

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