Caleb Donovick <donov...@cs.stanford.edu> added the comment:

Common python libraries that make use of environmental variables:
- django
- flask
- jupyter
- TensorFlow
This is just off the top my head.  While most developers are probably fine just 
setting the required variables at a system level that doesn't mean they should. 
 The whole point of virtual environments is to avoid global state.

Overriding setup scripts is hardly a trivial task.  One has to completely 
recreate the activate script to achieve the desired behavior.

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<https://bugs.python.org/issue37349>
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