Christian Heimes <li...@cheimes.de> added the comment:

'--with-openssl' purpose is to override the OpenSSL location for Python's 
internal _ssl and _hashlib module. It is not designed to interfere with 3rd 
party extensions that are built with distutils or setuptools.

It is the decision of a 3rd party package how it wants to handle these extra 
flags -- or if it is able to use them at all. In case of PyMySQL you must use 
the same shared libraries as libmysqlclient. You cannot use a  different 
OpenSSL ABIs, APIs, or shared libraries for PyMySQL and libmysqlclient.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue38577>
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