Raymond Hettinger <raymond.hettin...@gmail.com> added the comment:

This caused a performance regression (70%) for a fundamental operation.  See 
issue 37340.

Sometimes, bound methods are used directly and not through LOAD_METHOD:

     sorted(data, key=str.upper)

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nosy: +rhettinger
status: closed -> open

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue37340>
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