Inada Naoki <songofaca...@gmail.com> added the comment:

unpack_sequence is very sensitive benchmark. Speed is dramatically changed by 
code alignment. PGO+LTO will reduce the noise, but we see noise always.

I believe there is no significant performance change in macro benchmarks when 
optimizing this part.

Not significant in macro benchmarks doesn't mean we must reject the 
optimization, because pyperformance doesn't cover whole application in the 
world.
But it means that we must be conservative about the optimization.

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<https://bugs.python.org/issue41835>
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