Guido van Rossum <gu...@python.org> added the comment:

Do we have good intuition or data about which operations need speeding up most? 
Everybody always assumes it's BINARY_ADD, but much Python code isn't actually 
numeric, and binary operations aren't all that common. (For example, IIRC at my 
previous employer the hottest code was some kind of web template expansion and 
another bottleneck was marshalling RPC requests and results.)

Optimizers usually evolve to be excellent at optimizing the benchmark du jour 
-- what benchmark do we want to use?

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<https://bugs.python.org/issue42115>
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