Erlend Egeberg Aasland <erlend.aasl...@innova.no> added the comment:

Here's a list of the SQLite recommended compile-time options (only):

- macOS (v11.2.3) (SQLite v3.32.3) defines SQLITE_DEFAULT_WAL_SYNCHRONOUS=1
- Homebrew (SQLite v3.35.4) does not define any of the recommended compile-time 
options
- Debian Buster (SQLite v3.27.2) defines SQLITE_LIKE_DOESNT_MATCH_BLOBS
- Ubuntu 20.04 (SQLite v3.31.1) defines SQLITE_LIKE_DOESNT_MATCH_BLOBS

AFAICS, adding SQLITE_DEFAULT_MEMSTATUS=0 and SQLITE_OMIT_AUTOINIT is safe, as 
it only affects the C API that we use, and nothing else.

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<https://bugs.python.org/issue43851>
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