MeneMeneTekel <m...@evation.eu> added the comment:

Update: I just tried it again with 
 - Windows 10 Pro, 21H1
 - WinPython 3.9.4
 - Apache24
 - Django 3.2.4
 - mod_wsgi-4.8.0-cp39-cp39-win_amd64

Actually, there is no change, it got even worse. i.e. this wake up situation 
occurs more often. 

Remember: Changing WinPython 3.9.4 to WinPython 3.7.7 with 
mod_wsgi-4.7.1-cp37-cp37m-win_amd64 and all works fine!

Perhaps it's useful to have a stack trace? Here we are:

******
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819] mod_wsgi (pid=6556): Failed to exec Python script file 
'C:/.../.../.../wsgi.py'.
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819] mod_wsgi (pid=6556): Exception occurred processing WSGI 
script 'C:/.../.../.../wsgi.py'.
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819] Traceback (most recent call last):\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File "C:/.../.../.../wsgi.py", line 19, in <module>\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     application = get_wsgi_application()\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\core\\wsgi.py",
 line 13, in get_wsgi_application\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     return WSGIHandler()\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\core\\handlers\\wsgi.py",
 line 127, in __init__\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     self.load_middleware()\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\core\\handlers\\base.py",
 line 58, in load_middleware\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     mw_instance = middleware(adapted_handler)\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Users\\mail\\OneDrive\\Dokumente\\Privat\\Python\\Django\\Applications\\groupregister\\middleware\\sessions.py",
 line 54, in __init__\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     self.user_reg = get_user_model().objects \\\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\db\\models\\query.py",
 line 399, in aggregate\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     return query.get_aggregation(self.db, kwargs)\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\db\\models\\sql\\query.py",
 line 502, in get_aggregation\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     result = compiler.execute_sql(SINGLE)\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\db\\models\\sql\\compiler.py",
 line 1173, in execute_sql\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     cursor = self.connection.cursor()\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\site-packages\\django\\utils\\asyncio.py",
 line 19, in inner\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     event_loop = asyncio.get_event_loop()\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\asyncio\\events.py", line 
639, in get_event_loop\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     self.set_event_loop(self.new_event_loop())\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\asyncio\\events.py", line 
659, in new_event_loop\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     return self._loop_factory()\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\asyncio\\windows_events.py",
 line 310, in __init__\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     super().__init__(proactor)\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]   File 
"C:\\Winpython\\WPy64-3940\\python-3.9.4.amd64\\lib\\asyncio\\proactor_events.py",
 line 632, in __init__\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819]     signal.set_wakeup_fd(self._csock.fileno())\r
[Fri Jun 04 15:31:37.428939 2021] [wsgi:error] [pid 6556:tid 1140] [client 
111.222.333.444:50819] ValueError: set_wakeup_fd only works in main thread of 
the main interpreter\r
******

Would be nice to be able to switch zu Python 3.9.4 ff. soon...

Many thanks,
MeneMeneTekel

----------
versions: +Python 3.9 -Python 3.8

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<https://bugs.python.org/issue43007>
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