Serhiy Storchaka <storchaka+cpyt...@gmail.com> added the comment:

I am still not sure that it is worth to add 50 lines of the C code to optimize 
0.7% of calls.

You have found 70000 examples of function calls with 3 or 4 constant arguments. 
Does it include tests? Could you please show several (or several hundreds) 
non-test examples? I am wondering how much of them are in tight loops and are 
not just executed once at module initialization time.

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<https://bugs.python.org/issue44501>
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