Pablo Galindo Salgado <pablog...@gmail.com> added the comment:

If https://bugs.python.org/file50280/310rc2_benchmarks.txt is correct, this 
means that we have a 7% slowdown in Windows PGO builds for 3.10, which I don't 
think is acceptable.

I am marking this as a release blocker until there is some agreement. I remind 
you that if an agreement cannot be reached, you may reach the Steering Council 
for help reaching some conclusion.

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<https://bugs.python.org/issue45116>
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