Sebastian Berg <sebast...@sipsolutions.net> added the comment:

Thanks for having a look. I have confirmed this is related to Cython (no 
pandas/NumPy involved) – repro at https://github.com/seberg/bpo46451.  What 
happens under the hood in Cython is probably:
    
https://github.com/cython/cython/blob/master/Cython/Utility/ObjectHandling.c#L2569-L2611

Which generates `PyEval_EvalCodeEx`, and I could not repro with just a 
`PyObject_FastCallDict`, so I assume Cython is doing something wrong and will 
open an issue there, but if you have a quick tip as to what might wrong, that 
could be nice :).

Otherwise, will just close this, and may reopen if Cython hits a wall.

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<https://bugs.python.org/issue46451>
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