Ned Deily <n...@python.org> added the comment:

> I currently do not have access to a more up-to-date Mac OS but once I do I
will test and report anything unusual back.

Good luck! Since there's a good chance that this issue will languish in our 
open backlog, I am going to mark it as closed for now. But please re-open this 
issue if you find anything that appears to be an issue with Python rather than 
just macOS. Two other suggestions for debugging:
1. You've probably already done this but double-check file and directory access 
permissions on the NFS-mounted file system up to root. We have seen other 
issues with relative paths on 10.15+ with the introduction of the read-only 
system volume and related file system layout complications.
2. You might try using install_name_tool to alter copies of those third-party 
.so(s) and dylib(s) that use @rpath and instead use an absolute path to their 
installed location(s). That would eliminate one variable.

----------
resolution:  -> third party
stage:  -> resolved
status: open -> closed

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue46540>
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