STINNER Victor <vstin...@python.org> added the comment:

> For example, see _Py_abspath

For functions which are commonly called in Python at runtime, it may be worth 
it to manually merged large local variables to save a few bytes on the stack 
when Python is built with -O0. For _Py_abspath(), this function is only called 
at startup, if I recall correctly, so it should be a big issue in practice.

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<https://bugs.python.org/issue46600>
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