With the news of a GPL Qt4 for Windows, I decided to go with PyQt: http://mats.imk.fraunhofer.de/pipermail/pykde/2005-February/009527.html
I just knocked up my application (GUI, backend is still in progress) using QtDesigner in about 5 minutes, and it's layout is just how I want it! -- http://mail.python.org/mailman/listinfo/python-list