You have several option for interfacing with C libraries: Cython, swig, 
boost-python, ctypes ...

You can find several machine learning packages mentioned at 
http://web.media.mit.edu/~stefie10/technical/pythonml.html, I have no 
experience with any of them so I can't recommend any.

HTH
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Miki Tebeka <miki.teb...@gmail.com>
http://pythonwise.blogspot.com
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